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What is the article about?
- The Nobel Prize for Chemistry has been awarded to Carolyn Bertozzi, Morten Meldal and Barry Sharpless.
Relevance:
- GS3: Science and Technology- Developments and their Applications and Effects in Everyday Life; Prelims
Which of their research findings won the Nobel Prize?
- For the development of Click Chemistry. They have been pioneering ‘click chemistry’ or getting molecules that wouldn’t normally bond together to do so in an efficient and uncomplicated manner.
- The ‘click’ comes from an analogy Sharpless drew of molecules snapping together, like airline seat belts fitting into their buckles.
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Click chemistry, as the name suggests, is a way of building molecules like snapping Lego blocks together. It takes two molecules to click, so researchers refer to each one as click partners.
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Why is click chemistry needed?
- Historically, chemistry has sought to imitate nature. From medicine to fertilizer, the chemist has sought to make synthetic products that mimic natural molecules.
- On the other hand, several molecules have been synthesised in ingenious ways to create drugs and medicines to kill bacteria and relieve pain.
- The flip side is that these processes are likely laborious, and can create unwanted by-products, many toxic. Often, the number of intermediary steps is so great and complicated that the desired result is usually too expensive to be useful.
How does click chemistry work?
- Sharpless started on creating molecular building blocks — like Lego blocks — that could snap together quickly and efficiently.
- The first breakthrough came with discovering what has become the foundational stone of click chemistry, namely the copper catalysed azide-alkyne cycloaddition.
- Two kinds of chemicals — azides and alkynes — react very efficiently when copper ions are added and form a very stable structure called a triazole.
- Previous attempts to join azides and alkynes were cumbersome, but the trick this time was copper. From then on, if chemists wanted to link two different molecules, all that was required was to introduce an azide in one molecule and an alkyne in the other. They then snapped the molecules together with the help of some copper ions. This has now become an industry standard.
- However, Bertozzi took click chemistry to a new dimension and showed that it could be used in living organisms.
- Copper is toxic to living cells, but she figured out a way to produce a copper-free click reaction, called the strain-promoted azide-alkyne cycloaddition, and showed it could be used to treat tumours.
Way Forward:
- The awards demonstrate that it pays to rethink the fundamentals of a field and persevere at it for long enough to spark a revolution.
